Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

Ionizing radiation induces autophosphorylation of the ataxia-telangiectasia mutated (ATM) protein kinase on serine 1981; however, the precise mechanisms that regulate ATM activation are not fully understood. Here, we show that the protein phosphatase inhibitor okadaic acid (OA) induces autophosphory...

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Detalhes bibliográficos
Main Authors: Goodarzi, Aaron A, Jonnalagadda, Jyoti C, Douglas, Pauline, Young, David, Ye, Ruiqiong, Moorhead, Greg B G, Lees-Miller, Susan P, Khanna, Kum Kum
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC526470/
https://ncbi.nlm.nih.gov/pubmed/15510216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600455
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