Mutations of the RNase H C Helix of the Moloney Murine Leukemia Virus Reverse Transcriptase Reveal Defects in Polypurine Tract Recognition

Both the RNase H domain of Moloney murine leukemia virus (Mo-MLV) reverse transcriptase (RT) and Escherichia coli RNase H possess a positively charged α-helix (C helix) and a loop that are not present in the RNase H domains of human immunodeficiency virus (HIV) RT or avian sarcoma virus RT. Although...

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Pubblicato in:	J Virol
Autori principali:	Lim, David, Orlova, Marianna, Goff, Stephen P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12134040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.16.8360-8373.2002
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