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Mutations of the RNase H C Helix of the Moloney Murine Leukemia Virus Reverse Transcriptase Reveal Defects in Polypurine Tract Recognition

Both the RNase H domain of Moloney murine leukemia virus (Mo-MLV) reverse transcriptase (RT) and Escherichia coli RNase H possess a positively charged α-helix (C helix) and a loop that are not present in the RNase H domains of human immunodeficiency virus (HIV) RT or avian sarcoma virus RT. Although...

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Detalhes bibliográficos
Main Authors: Lim, David, Orlova, Marianna, Goff, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155118/
https://ncbi.nlm.nih.gov/pubmed/12134040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.16.8360-8373.2002
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