Mutations of the RNase H C Helix of the Moloney Murine Leukemia Virus Reverse Transcriptase Reveal Defects in Polypurine Tract Recognition

Both the RNase H domain of Moloney murine leukemia virus (Mo-MLV) reverse transcriptase (RT) and Escherichia coli RNase H possess a positively charged α-helix (C helix) and a loop that are not present in the RNase H domains of human immunodeficiency virus (HIV) RT or avian sarcoma virus RT. Although...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lim, David, Orlova, Marianna, Goff, Stephen P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12134040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.16.8360-8373.2002
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