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RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template.

The active sites for the polymerase and nuclease activities of Moloney murine leukemia virus (M-MuLV) reverse transcriptase (RT) reside in separate domains of a single polypeptide. We have studied the effects of RNase H domain mutations on DNA polymerase activity. These mutant RTs displayed decrease...

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Bibliografiske detaljer
Main Authors: Telesnitsky, A, Goff, S P
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC45855/
https://ncbi.nlm.nih.gov/pubmed/7679498
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