Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy

Activation of mammalian sterile 20–like kinase 1 (Mst1) by genotoxic compounds is known to stimulate apoptosis in some cell types. The importance of Mst1 in cell death caused by clinically relevant pathologic stimuli is unknown, however. In this study, we show that Mst1 is a prominent myelin basic p...

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Détails bibliographiques
Auteurs principaux: Yamamoto, Shimako, Yang, Guiping, Zablocki, Daniela, Liu, Jing, Hong, Chull, Kim, Song-Jung, Soler, Sandra, Odashima, Mari, Thaisz, Jill, Yehia, Ghassan, Molina, Carlos A., Yatani, Atsuko, Vatner, Dorothy E., Vatner, Stephen F., Sadoshima, Junichi
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC155047/
https://ncbi.nlm.nih.gov/pubmed/12750396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317459
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