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Benefit of farnesoid X receptor inhibition in obstructive cholestasis

The nuclear hormone receptors farnesoid X receptor (FXR) and pregnane X receptor have been implicated in regulating bile acid, lipid, carbohydrate, and xenobiotic metabolism. Bile duct ligation was used to increase endogenous bile acids and evaluate the roles of these receptors in modulating cholest...

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Bibliographische Detailangaben
Hauptverfasser: Stedman, Catherine, Liddle, Christopher, Coulter, Sally, Sonoda, Junichiro, Alvarez, Jacqueline G., Evans, Ronald M., Downes, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544085/
https://ncbi.nlm.nih.gov/pubmed/16844773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604772103
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