Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis

Cholestasis is a common complication of sepsis, and the increased plasma levels of bile acids are predictive of sepsis-associated mortality. However, the exact mechanism by which cholestasis aggravates sepsis development remains elusive. Here, we show that bile acids are danger-associated molecular...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Hao, Haiping, Cao, Lijuan, Jiang, Changtao, Che, Yuan, Zhang, Songyang, Takahashi, Shogo, Wang, Guangji, Gonzalez, Frank J.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624427/
https://ncbi.nlm.nih.gov/pubmed/28380377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.03.007
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