Wordt geladen...

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) isozymes to different extents, which accounts for their anti-inflammatory and analgesic activities and their gastrointestinal side effects. We have exploited biochemical differences between the two COX enzymes to ident...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Kalgutkar, Amit S., Crews, Brenda C., Rowlinson, Scott W., Marnett, Alan B., Kozak, Kevin R., Remmel, Rory P., Marnett, Lawrence J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2000
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC15432/
https://ncbi.nlm.nih.gov/pubmed/10639181
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!