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Programming CD8(+) T cells for effective immunotherapy

The differentiation state of CD8(+) T cells has emerged as a crucial determinant of their ability to respond to tumor and infection. Signals from T-cell receptors, co-stimulatory molecules and cytokine receptors direct the differentiation process. These signals ‘program’ sustained and heritable gene...

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Bibliographic Details
Main Authors: Hinrichs, Christian S, Gattinoni, Luca, Restifo, Nicholas P
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1540013/
https://ncbi.nlm.nih.gov/pubmed/16616471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2006.03.009
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