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Pathogenesis of Herpes Simplex Virus Type 2 Virion Host Shutoff (vhs) Mutants

During lytic infection, the virion host shutoff (vhs) protein mediates the rapid degradation of mRNA and the shutoff of host protein synthesis. In vivo, herpes simplex virus type 1 (HSV-1) mutants lacking vhs activity are profoundly attenuated. Homologs of vhs exist in all of the neurotropic herpesv...

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Sonraí Bibleagrafaíochta
Main Authors: Smith, Tracy J., Morrison, Lynda A., Leib, David A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC153813/
https://ncbi.nlm.nih.gov/pubmed/11836383
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