Pathogenesis of Herpes Simplex Virus Type 2 Virion Host Shutoff (vhs) Mutants

During lytic infection, the virion host shutoff (vhs) protein mediates the rapid degradation of mRNA and the shutoff of host protein synthesis. In vivo, herpes simplex virus type 1 (HSV-1) mutants lacking vhs activity are profoundly attenuated. Homologs of vhs exist in all of the neurotropic herpesv...

Full description

Bibliographic Details

Published in:	J Virol
Main Authors:	Smith, Tracy J., Morrison, Lynda A., Leib, David A.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2002
Subjects:	Pathogenesis and Immunity
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11836383/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.76.5.2054-2061.2002
Tags:	Add Tag No Tags, Be the first to tag this record!