DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair

The yeast Mlh1–Pms1 heterodimer required for mismatch repair (MMR) binds to DNA. Here we map DNA binding to N-terminal fragments of Mlh1 and Pms1. We demonstrate that Mlh1 and Pms1 N-terminal domains (NTDs) independently bind to double-stranded and single-stranded DNA, in the absence of dimerization...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Hall, Mark C., Shcherbakova, Polina V., Fortune, John M., Borchers, Christoph H., Dial, J. Michael, Tomer, Kenneth B., Kunkel, Thomas A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 2003
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153752/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12682353/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg324
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