Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

The hypoxic tumor microenvironment has been shown to contribute to genetic instability. As one possible mechanism for this effect, we report that expression of the DNA mismatch repair (MMR) gene Mlh1 is specifically reduced in mammalian cells under hypoxia, whereas expression of other MMR genes, inc...

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Detalhes bibliográficos
Main Authors: Mihaylova, Valia T., Bindra, Ranjit S., Yuan, Jianling, Campisi, Denise, Narayanan, Latha, Jensen, Ryan, Giordano, Frank, Johnson, Randall S., Rockwell, Sara, Glazer, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153206/
https://ncbi.nlm.nih.gov/pubmed/12697826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3265-3273.2003
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