Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

The hypoxic tumor microenvironment has been shown to contribute to genetic instability. As one possible mechanism for this effect, we report that expression of the DNA mismatch repair (MMR) gene Mlh1 is specifically reduced in mammalian cells under hypoxia, whereas expression of other MMR genes, inc...

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Autors principals: Mihaylova, Valia T., Bindra, Ranjit S., Yuan, Jianling, Campisi, Denise, Narayanan, Latha, Jensen, Ryan, Giordano, Frank, Johnson, Randall S., Rockwell, Sara, Glazer, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC153206/
https://ncbi.nlm.nih.gov/pubmed/12697826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3265-3273.2003
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