Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

The hypoxic tumor microenvironment has been shown to contribute to genetic instability. As one possible mechanism for this effect, we report that expression of the DNA mismatch repair (MMR) gene Mlh1 is specifically reduced in mammalian cells under hypoxia, whereas expression of other MMR genes, inc...

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Dettagli Bibliografici

Pubblicato in:	Mol Cell Biol
Autori principali:	Mihaylova, Valia T., Bindra, Ranjit S., Yuan, Jianling, Campisi, Denise, Narayanan, Latha, Jensen, Ryan, Giordano, Frank, Johnson, Randall S., Rockwell, Sara, Glazer, Peter M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12697826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.9.3265-3273.2003
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