Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

The hypoxic tumor microenvironment has been shown to contribute to genetic instability. As one possible mechanism for this effect, we report that expression of the DNA mismatch repair (MMR) gene Mlh1 is specifically reduced in mammalian cells under hypoxia, whereas expression of other MMR genes, inc...

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Bibliographic Details
Main Authors: Mihaylova, Valia T., Bindra, Ranjit S., Yuan, Jianling, Campisi, Denise, Narayanan, Latha, Jensen, Ryan, Giordano, Frank, Johnson, Randall S., Rockwell, Sara, Glazer, Peter M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153206/
https://ncbi.nlm.nih.gov/pubmed/12697826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3265-3273.2003
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