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DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair

The yeast Mlh1–Pms1 heterodimer required for mismatch repair (MMR) binds to DNA. Here we map DNA binding to N-terminal fragments of Mlh1 and Pms1. We demonstrate that Mlh1 and Pms1 N-terminal domains (NTDs) independently bind to double-stranded and single-stranded DNA, in the absence of dimerization...

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Bibliografiske detaljer
Main Authors: Hall, Mark C., Shcherbakova, Polina V., Fortune, John M., Borchers, Christoph H., Dial, J. Michael, Tomer, Kenneth B., Kunkel, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC153752/
https://ncbi.nlm.nih.gov/pubmed/12682353
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