Systematic Mutagenesis of the Saccharomyces cerevisiae MLH1 Gene Reveals Distinct Roles for Mlh1p in Meiotic Crossing Over and in Vegetative and Meiotic Mismatch Repair

In eukaryotic cells, DNA mismatch repair is initiated by a conserved family of MutS (Msh) and MutL (Mlh) homolog proteins. Mlh1 is unique among Mlh proteins because it is required in mismatch repair and for wild-type levels of crossing over during meiosis. In this study, 60 new alleles of MLH1 were...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Argueso, Juan Lucas, Kijas, Amanda Wraith, Sarin, Sumeet, Heck, Julie, Waase, Marc, Alani, Eric
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140715/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12529393/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.3.873-886.2003
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