c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and maintenance. Starting from an expression-profiling screen, we identified c-myc as a direct target of Notch1 in Notch-dependent T-A...

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Autori principali: Weng, Andrew P., Millholland, John M., Yashiro-Ohtani, Yumi, Arcangeli, Marie Laure, Lau, Arthur, Wai, Carol, del Bianco, Cristina, Rodriguez, Carlos G., Sai, Hong, Tobias, John, Li, Yueming, Wolfe, Michael S., Shachaf, Cathy, Felsher, Dean, Blacklow, Stephen C., Pear, Warren S., Aster, Jon C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2006
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1536060/
https://ncbi.nlm.nih.gov/pubmed/16847353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1450406
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