Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK

The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing physiological regulators of HSC expansion. Lnk(−/−) HSCs continue to expand postnatally, up to 24-fold above...

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Hlavní autoři: Buza-Vidas, Natalija, Antonchuk, Jennifer, Qian, Hong, Månsson, Robert, Luc, Sidinh, Zandi, Sasan, Anderson, Kristina, Takaki, Satoshi, Nygren, Jens M., Jensen, Christina T., Jacobsen, Sten Eirik W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2006
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1536053/
https://ncbi.nlm.nih.gov/pubmed/16882979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.385606
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