Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK

The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing physiological regulators of HSC expansion. Lnk(−/−) HSCs continue to expand postnatally, up to 24-fold above...

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書誌詳細
主要な著者: Buza-Vidas, Natalija, Antonchuk, Jennifer, Qian, Hong, Månsson, Robert, Luc, Sidinh, Zandi, Sasan, Anderson, Kristina, Takaki, Satoshi, Nygren, Jens M., Jensen, Christina T., Jacobsen, Sten Eirik W.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2006
主題:
Research Communication
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1536053/
https://ncbi.nlm.nih.gov/pubmed/16882979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.385606
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