Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK

The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing physiological regulators of HSC expansion. Lnk(−/−) HSCs continue to expand postnatally, up to 24-fold above...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Buza-Vidas, Natalija, Antonchuk, Jennifer, Qian, Hong, Månsson, Robert, Luc, Sidinh, Zandi, Sasan, Anderson, Kristina, Takaki, Satoshi, Nygren, Jens M., Jensen, Christina T., Jacobsen, Sten Eirik W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cold Spring Harbor Laboratory Press 2006
विषय:
Research Communication
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1536053/
https://ncbi.nlm.nih.gov/pubmed/16882979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.385606
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