Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK

The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing physiological regulators of HSC expansion. Lnk(−/−) HSCs continue to expand postnatally, up to 24-fold above...

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Detalhes bibliográficos
Main Authors: Buza-Vidas, Natalija, Antonchuk, Jennifer, Qian, Hong, Månsson, Robert, Luc, Sidinh, Zandi, Sasan, Anderson, Kristina, Takaki, Satoshi, Nygren, Jens M., Jensen, Christina T., Jacobsen, Sten Eirik W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1536053/
https://ncbi.nlm.nih.gov/pubmed/16882979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.385606
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