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p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes
BACKGROUND: p14ARF is a protein product of the alternative reading frame of the human INK4a locus. It functions as a tumor suppressor protein. p14ARF suppresses growth through p53-dependent and p53-independent pathways. RESULTS: p14ARF protein localizes primarily to the nucleoli. Here we show that i...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC153488/ https://ncbi.nlm.nih.gov/pubmed/12685933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-2-18 |
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