p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes

BACKGROUND: p14ARF is a protein product of the alternative reading frame of the human INK4a locus. It functions as a tumor suppressor protein. p14ARF suppresses growth through p53-dependent and p53-independent pathways. RESULTS: p14ARF protein localizes primarily to the nucleoli. Here we show that i...

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Bibliographic Details
Main Authors: Kashuba, Elena, Mattsson, Karin, Klein, George, Szekely, Laszlo
Format: Artigo
Language:Inglês
Published: BioMed Central 2003
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153488/
https://ncbi.nlm.nih.gov/pubmed/12685933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-2-18
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