p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes
BACKGROUND: p14ARF is a protein product of the alternative reading frame of the human INK4a locus. It functions as a tumor suppressor protein. p14ARF suppresses growth through p53-dependent and p53-independent pathways. RESULTS: p14ARF protein localizes primarily to the nucleoli. Here we show that i...
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| Publicat a: | Mol Cancer |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153488/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12685933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1476-4598-2-18 |
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