p14(ARF )expression in invasive breast cancers and ductal carcinoma in situ – relationships to p53 and Hdm2

INTRODUCTION: p14(ARF )stabilises nuclear p53, with a variable expression of p14(ARF )mRNA in breast cancers. In vitro, nuclear p14(ARF )binds Hdm2 to block Hdm2-dependent nucleocytoplasmic shuttling of p53, which is required before cytoplasmic degradation of p53. p14(ARF )is negatively regulated by...

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Detalhes bibliográficos
Main Authors: Vestey, SB, Sen, C, Calder, CJ, Perks, CM, Pignatelli, M, Winters, ZE
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC549173/
https://ncbi.nlm.nih.gov/pubmed/15318938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr912
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