Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax: Evidence for Sequential Selection by Drug Pressure

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained from 55 P. vivax isolates (isolates Belem and Sal 1, which are established lines originating from Lat...

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Εκδόθηκε σε:	Antimicrob Agents Chemother
Κύριοι συγγραφείς:	Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, Looareesuwan, Sornchai, White, Nicholas J., Snounou, Georges
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2003
Θέματα:	Mechanisms of Resistance
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12709316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.5.1514-1521.2003
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