Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax: Evidence for Sequential Selection by Drug Pressure

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained from 55 P. vivax isolates (isolates Belem and Sal 1, which are established lines originating from Lat...

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Bibliografiset tiedot

Julkaisussa:	Antimicrob Agents Chemother
Päätekijät:	Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, Looareesuwan, Sornchai, White, Nicholas J., Snounou, Georges
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 2003
Aiheet:	Mechanisms of Resistance
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12709316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.5.1514-1521.2003
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