Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax: Evidence for Sequential Selection by Drug Pressure

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained from 55 P. vivax isolates (isolates Belem and Sal 1, which are established lines originating from Lat...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, Looareesuwan, Sornchai, White, Nicholas J., Snounou, Georges
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Assuntos:	Mechanisms of Resistance
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12709316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.5.1514-1521.2003
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