Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax: Evidence for Sequential Selection by Drug Pressure

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained from 55 P. vivax isolates (isolates Belem and Sal 1, which are established lines originating from Lat...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, Looareesuwan, Sornchai, White, Nicholas J., Snounou, Georges
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2003
Témata:	Mechanisms of Resistance
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12709316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.5.1514-1521.2003
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