Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax: Evidence for Sequential Selection by Drug Pressure

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained from 55 P. vivax isolates (isolates Belem and Sal 1, which are established lines originating from Lat...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, Looareesuwan, Sornchai, White, Nicholas J., Snounou, Georges
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2003
الموضوعات:
Mechanisms of Resistance
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC153323/
https://ncbi.nlm.nih.gov/pubmed/12709316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.5.1514-1521.2003
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