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Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region
Genetic studies have implicated the cytosolic juxtamembrane region of the Kit receptor tyrosine kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain are associated with cancers, such as gastrointestinal stromal tumors and mastocytosis, and result in constitutive activ...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC153186/ https://ncbi.nlm.nih.gov/pubmed/12697809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3067-3078.2003 |
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