Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region

Genetic studies have implicated the cytosolic juxtamembrane region of the Kit receptor tyrosine kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain are associated with cancers, such as gastrointestinal stromal tumors and mastocytosis, and result in constitutive activ...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Chan, Perry M., Ilangumaran, Subburaj, La Rose, Jose, Chakrabartty, Avijit, Rottapel, Robert
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153186/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12697809/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.9.3067-3078.2003
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