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Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region

Genetic studies have implicated the cytosolic juxtamembrane region of the Kit receptor tyrosine kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain are associated with cancers, such as gastrointestinal stromal tumors and mastocytosis, and result in constitutive activ...

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Bibliografski detalji
Glavni autori: Chan, Perry M., Ilangumaran, Subburaj, La Rose, Jose, Chakrabartty, Avijit, Rottapel, Robert
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC153186/
https://ncbi.nlm.nih.gov/pubmed/12697809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3067-3078.2003
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