Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region

Genetic studies have implicated the cytosolic juxtamembrane region of the Kit receptor tyrosine kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain are associated with cancers, such as gastrointestinal stromal tumors and mastocytosis, and result in constitutive activ...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Chan, Perry M., Ilangumaran, Subburaj, La Rose, Jose, Chakrabartty, Avijit, Rottapel, Robert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153186/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12697809/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.9.3067-3078.2003
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