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Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and insulin, are critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2), respectively. We previously identified IDE as a principal regulator of Aβ levels in neuronal and mic...

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Bibliografski detalji
Glavni autori: Farris, Wesley, Mansourian, Stefan, Chang, Yang, Lindsley, Loren, Eckman, Elizabeth A., Frosch, Matthew P., Eckman, Christopher B., Tanzi, Rudolph E., Selkoe, Dennis J., Guénette, Suzanne
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC153065/
https://ncbi.nlm.nih.gov/pubmed/12634421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0230450100
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