Pharmacological targeting of the β-amyloid precursor protein intracellular domain

Amyloid precursor protein (APP) intracellular domain (AICD) is a product of APP processing with transcriptional modulation activity, whose overexpression causes various Alzheimer's disease (AD)-related dysfunctions. Here we report that 1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropan...

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Detalhes bibliográficos
Main Authors: Branca, Caterina, Sarnico, Ilenia, Ruotolo, Roberta, Lanzillotta, Annamaria, Viscomi, Arturo Roberto, Benarese, Marina, Porrini, Vanessa, Lorenzini, Luca, Calzà, Laura, Imbimbo, Bruno Pietro, Ottonello, Simone, Pizzi, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980230/
https://ncbi.nlm.nih.gov/pubmed/24714650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04618
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