Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and insulin, are critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2), respectively. We previously identified IDE as a principal regulator of Aβ levels in neuronal and mic...

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Detalhes bibliográficos
Main Authors: Farris, Wesley, Mansourian, Stefan, Chang, Yang, Lindsley, Loren, Eckman, Elizabeth A., Frosch, Matthew P., Eckman, Christopher B., Tanzi, Rudolph E., Selkoe, Dennis J., Guénette, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153065/
https://ncbi.nlm.nih.gov/pubmed/12634421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0230450100
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