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The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: Lessons for protein design?

The mechanism of formation of β-sheets is of great importance because of the significant role of such structures in the initiation and propagation of amyloid diseases. In this study we examine the folding of a series of three-stranded antiparallel β-sheets known as WW domains. Whereas other WW domai...

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Autori principali: Karanicolas, John, Brooks, Charles L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153029/
https://ncbi.nlm.nih.gov/pubmed/12655041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0731771100
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