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Integrating folding kinetics and protein function: Biphasic kinetics and dual binding specificity in a WW domain

Because of the association of β-sheet formation with the initiation and propagation of amyloid diseases, model systems have been sought to further our understanding of this process. WW domains have been proposed as one such model system. Whereas the folding of the WW domains from human Yes-associate...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Karanicolas, John, Brooks, Charles L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373479/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14981252/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0304825101
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