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Dominant folding pathways of a WW domain

We investigate the folding mechanism of the WW domain Fip35 using a realistic atomistic force field by applying the Dominant Reaction Pathways approach. We find evidence for the existence of two folding pathways, which differ by the order of formation of the two hairpins. This result is consistent w...

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Detalhes bibliográficos
Main Authors: a Beccara, Silvio, Škrbić, Tatjana, Covino, Roberto, Faccioli, Pietro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289289/
https://ncbi.nlm.nih.gov/pubmed/22308345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111796109
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