Ultrafast folding kinetics of WW domains reveal how the amino acid sequence determines the speed limit to protein folding

Protein (un)folding rates depend on the free-energy barrier separating the native and unfolded states and a prefactor term, which sets the timescale for crossing such barrier or folding speed limit. Because extricating these two factors is usually unfeasible, it has been common to assume a constant...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Szczepaniak, Malwina, Iglesias-Bexiga, Manuel, Cerminara, Michele, Sadqi, Mourad, Sanchez de Medina, Celia, Martinez, Jose C., Luque, Irene, Muñoz, Victor
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486773/
https://ncbi.nlm.nih.gov/pubmed/30967507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900203116
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