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A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition

A rhodium(III) complex, rac-[Rh(bpy)(2)phzi](3+) (bpy, 2,2′-bipyridine; phzi, benzo[a]phenazine-5,6-quinone diimine) has been designed as a sterically demanding intercalator targeted to destabilized mismatched sites in double-helical DNA. The complex is readily synthesized by condensation of the phe...

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Auteurs principaux: Junicke, Henrik, Hart, Jonathan R., Kisko, Jennifer, Glebov, Oleg, Kirsch, Ilan R., Barton, Jacqueline K.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC152991/
https://ncbi.nlm.nih.gov/pubmed/12610209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0537194100
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