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Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator
We report the 1.1-Å resolution crystal structure of a bulky rhodium complex bound to two different DNA sites, mismatched and matched in the oligonucleotide 5′-(dCGGAAATTCCCG)(2)-3′. At the AC mismatch site, the structure reveals ligand insertion from the minor groove with ejection of both mismatched...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766401/ https://ncbi.nlm.nih.gov/pubmed/17194756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610170104 |
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