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DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications
The syntheses and applications of two metallointercalators, Rh(bpy)(2)(chrysi)(3+) and Rh(bpy)(2)(phzi)(3+), that target single base mismatches in DNA are described. The complexes selectively bind thermodynamically destabilized mismatched DNA sites and, upon photoactivation, promote strand scission...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754800/ https://ncbi.nlm.nih.gov/pubmed/17406597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2007.22 |
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