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Crystal structure of Δ-Ru(bpy)(2)dppz(2+) bound to mismatched DNA reveals side-by-side metalloinsertion and intercalation

DNA mismatches represent a novel target in developing diagnostics and therapeutics for cancer, since deficiencies in DNA-mismatch repair (MMR) are implicated in many cancers and cells that are MMR-deficient show a high frequency of mismatches. We use metal complexes with bulky intercalating ligands...

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Autores principales: Song, Hang, Kaiser, Jens T., Barton, Jacqueline K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478149/
https://ncbi.nlm.nih.gov/pubmed/22824892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1375
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