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Crystal structure of Δ-Ru(bpy)(2)dppz(2+) bound to mismatched DNA reveals side-by-side metalloinsertion and intercalation
DNA mismatches represent a novel target in developing diagnostics and therapeutics for cancer, since deficiencies in DNA-mismatch repair (MMR) are implicated in many cancers and cells that are MMR-deficient show a high frequency of mismatches. We use metal complexes with bulky intercalating ligands...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478149/ https://ncbi.nlm.nih.gov/pubmed/22824892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1375 |
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