MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides

Exposure of Pseudomonas aeruginosa to aminoglycosides frequently selects for recalcitrant subpopulations exhibiting an unstable, “adaptive” resistance to these antibiotics. In this study, we investigated the implication in the phenomenon of MexXY-OprM, an active efflux system known to export aminogl...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Hocquet, Didier, Vogne, Christelle, El Garch, Farid, Vejux, Anne, Gotoh, Naomasa, Lee, Angela, Lomovskaya, Olga, Plésiat, Patrick
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152483/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654672/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.4.1371-1375.2003
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