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MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides

Exposure of Pseudomonas aeruginosa to aminoglycosides frequently selects for recalcitrant subpopulations exhibiting an unstable, “adaptive” resistance to these antibiotics. In this study, we investigated the implication in the phenomenon of MexXY-OprM, an active efflux system known to export aminogl...

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Main Authors: Hocquet, Didier, Vogne, Christelle, El Garch, Farid, Vejux, Anne, Gotoh, Naomasa, Lee, Angela, Lomovskaya, Olga, Plésiat, Patrick
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC152483/
https://ncbi.nlm.nih.gov/pubmed/12654672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1371-1375.2003
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