MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides

Exposure of Pseudomonas aeruginosa to aminoglycosides frequently selects for recalcitrant subpopulations exhibiting an unstable, “adaptive” resistance to these antibiotics. In this study, we investigated the implication in the phenomenon of MexXY-OprM, an active efflux system known to export aminogl...

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Detalhes bibliográficos
Main Authors: Hocquet, Didier, Vogne, Christelle, El Garch, Farid, Vejux, Anne, Gotoh, Naomasa, Lee, Angela, Lomovskaya, Olga, Plésiat, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152483/
https://ncbi.nlm.nih.gov/pubmed/12654672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1371-1375.2003
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