Extrusion of Penem Antibiotics by Multicomponent Efflux Systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa

The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC β-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each s...

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Hlavní autoři: Okamoto, Kiyomi, Gotoh, Naomasa, Nishino, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127373/
https://ncbi.nlm.nih.gov/pubmed/12121960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2696-2699.2002
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